A prostate-specific antigen (PSA) test measures the amount of prostate-specific antigen in the blood. PSA is released into a man's blood by his prostate gland . Healthy men have low amounts of PSA in the blood. The amount of PSA in the blood normally increases as a man's prostate enlarges with age. PSA may increase as a result of an injury, a digital rectal exam , sexual activity ( ejaculation ), inflammation of the prostate gland ( prostatitis ), or prostate cancer .
Prostate cancer often grows very slowly, without causing major problems. Detecting prostate cancer early and treating it may prevent some health problems and reduce the risk of dying from the cancer. However, some treatments for prostate cancer can cause other problems, such as controlling urination (incontinence) or erection problems (erectile dysfunction). Some men may choose not to have a PSA test or treat prostate cancer if it is detected. For example, a man older than age 75 who has no bothersome symptoms of prostate cancer may choose not to treat the cancer if it is found, so he would not need a PSA test.
Biology of Prostate-Specific Antigen
Prostate-specific antigen (PSA) is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. Prostate specific antigen (PSA) is a protein produced by the cells of the prostate gland. Prostate-specific antigen is present in small quantities in the serum of normal men, and is often elevated in the presence of prostate cancer and in other prostate disorders.
PSA is a major protein in semen , where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244–amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. PSA that enters the circulation intact is rapidly bound by protease inhibitors, primarily alpha1-antichymotrypsin, although a fraction is inactivated in the lumen by proteolysis and circulates as free PSA
A PSA blood test is the most effective test currently available for the early detection of prostate cancer. Higher than normal levels of PSA are associated with both localized and metastatic prostate cancer (CaP).
Prostate-specific antigen (PSA), also known as kallikrein III, seminin, semenogelase, γ-seminoprotein and P-30 antigen is a 34 kD glycoprotein manufactured almost exclusively by the prostate gland; PSA is produced for the ejaculate where it liquifies the semen and allows sperm to swim freely. It is also believed to be instrumental in dissolving the cervical mucous cap, allowing the entry of sperm.
In addition to measuring human Prostate Specific Antigen in blood, tissue samples can be stained for the presence of PSA in order to determine the origin of maligant cells that have metastasized.
PSA is a major protein in semen , where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244–amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. PSA that enters the circulation intact is rapidly bound by protease inhibitors, primarily alpha1-antichymotrypsin, although a fraction is inactivated in the lumen by proteolysis and circulates as free PSA
A PSA blood test is the most effective test currently available for the early detection of prostate cancer. Higher than normal levels of PSA are associated with both localized and metastatic prostate cancer (CaP).
Prostate-specific antigen (PSA), also known as kallikrein III, seminin, semenogelase, γ-seminoprotein and P-30 antigen is a 34 kD glycoprotein manufactured almost exclusively by the prostate gland; PSA is produced for the ejaculate where it liquifies the semen and allows sperm to swim freely. It is also believed to be instrumental in dissolving the cervical mucous cap, allowing the entry of sperm.
In addition to measuring human Prostate Specific Antigen in blood, tissue samples can be stained for the presence of PSA in order to determine the origin of maligant cells that have metastasized.
Prostate-Specific Antigen Levels as a Predictor of Lethal Prostate Cancer
Prostate-Specific Antigen Levels as a Predictor of Lethal Prostate Cancer . Rates of long-term survival among patients with untreated localized prostate cancer are high. To avoid unnecessary treatment, tools are needed to identify the small proportion of patients who are destined to develop lethal prostate cancer. Conclusions: Although baseline PSA value and rate of PSA change are prognostic factors for lethal prostate cancer, they are poor predictors of lethal prostate cancer among patients with localized prostate cancer who are managed by watchful waiting. Source: Journal of the National Cancer Institute 2007 99(7):526-532; doi:10.1093/jnci/djk110
Human Prostate Specific Antigen and Acid Phosphatase Cancer Research Needs
Lee Biosolutions specializes in the development and purification of high quality BioMarkers for the Immunodiagnostic, clinical diagnostic and pharmaceutical industry worldwide. Demand for high quality human semen proteins such as Human Prostate Specific Antigen and Human Acid Phosphatase PAP has increased significantly due to increase cancer research. As a result we have had collect over 10 liters of Human Semen every year to meet this demand from qualified donors.
Human Tumor Marker PSA has been highly purified to meet current human prostate cancer research requirements. Human Prostate specific antigen is a protein produced by the cells of the prostate gland and Prostate Specific Antigen is highly specific for prostatic tissue.
Human tumor marker Human Prostate Specific Antigen is present in small quantities in the serum of normal men, and is often elevated in the presence of prostate cancer and in other prostate disorders. A blood test to measure Human Prostate Specific Antigen is the most effective test currently available for the early detection of prostate cancer.
Lee Biosolutions has also added matched polyclonal antibodies such as, PSA Antibody to the product line.
Human Tumor Marker PSA has been highly purified to meet current human prostate cancer research requirements. Human Prostate specific antigen is a protein produced by the cells of the prostate gland and Prostate Specific Antigen is highly specific for prostatic tissue.
Human tumor marker Human Prostate Specific Antigen is present in small quantities in the serum of normal men, and is often elevated in the presence of prostate cancer and in other prostate disorders. A blood test to measure Human Prostate Specific Antigen is the most effective test currently available for the early detection of prostate cancer.
Lee Biosolutions has also added matched polyclonal antibodies such as, PSA Antibody to the product line.
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